ARIA — Autonomous Research Intelligence Architecture

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Scientific file library

Name	Type	Owner	Date modified	File size

01 · Idea Engine

Brainstorm to breakthrough.

Citations

All papers

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0 selected · click + Add on each paper to include it in the literature review

02 · Sandbox · 🚧 Under construction

Simulate before bench execution.

ARIA Sandbox

Describe any experimental protocol in plain language. I'll break it into steps, decide which instruments to simulate for each step, and run them sequentially — no coding required.

I want to quantify BSA in PBS pH 7.4 at room temperature. The sample is ~1 mg/mL. I need a full absorbance spectrum and a calibration curve.

ARIA Sandbox

I've broken your protocol into 2 simulation steps and selected the appropriate instruments:

Step 01 — UV-Vis Spectrophotometer · Full absorbance spectrum 200–800 nm

Step 02 — UV-Vis Spectrophotometer · Calibration curve A₂₈₀ vs concentration (0.1–2.0 mg/mL)

Input completeness

86%

Core concentration, buffer, pH, and temperature are present.

Confidence score

0.91

High match to UV-Vis protein quantification training cases.

Bench readiness

82%

Ready after path length and blanking conditions are confirmed.

Missing variables

2

Cuvette path length and baseline correction method.

Reproducibility risk

Low

Main risk is matrix interference near A280.

Assumptions

3

Quartz cuvette, 1 cm path, PBS blank subtraction.

Validation recommendation

Run three replicate blanks and a five-point standard curve before using the output as bench guidance.

Running simulations now...

ARIA Sandbox

✓ Step 01 complete — UV-Vis full spectrum (200–800 nm)

01

Full Absorbance Spectrum

UV-Vis Spectrophotometer · BSA 1 mg/mL

1.42

A₂₈₀

1.84

A₂₆₀

1.30

A260/A280

280 nm

λmax

ARIA Sandbox

✓ Step 02 complete — Calibration curve (0.1–2.0 mg/mL)

02

Calibration Curve

UV-Vis Spectrophotometer · A₂₈₀ vs concentration

0.9991

R²

0.04

LOD mg/mL

1.42

ε₂₈₀ slope

$847

Cost saved

Both simulations complete. The calibration is linear across the full range (R²=0.9991) with a detection limit of 0.04 mg/mL. Want me to adjust any parameters or run an additional step — for example a temperature sensitivity sweep?

UV-Vis Spectrum — BSA 1 mg/mL

PNG · 600 DPI · Saved from Sandbox

Sandbox · Run #14

Calibration Curve — BSA A280

PNG · 600 DPI · Saved from Sandbox

Sandbox · Run #14

Temperature Sensitivity Sweep

PNG · 600 DPI · 4–37°C range

Sandbox · Run #12

Figure 1 — Absorbance Spectrum

TIFF · 600 DPI · Manuscript figure

Document Studio

Figure 2 — Error Bars (n=3)

TIFF · 600 DPI · Manuscript figure

Document Studio

Add figure

04 · Journal Intelligence

Publication readiness system.

Journal match

Formatting compliance

Figure check

Submission checklist

05 · Lab OS

Lab OS

Personal information

Your name, role, and where you do your science.

Display name

Role

Affiliation

Research interests

Short phrases or comma-separated tags. Used for matching with collaborators.

Bio

ORCID iD

Format: 0000-0000-0000-000X

Email

Sign-in address for your account. Changing it requires confirming the new address.

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verified

New email address

Current password

A verification link will be sent to your new address. The change takes effect after you click it.

Password

Change your password. After saving, you'll stay signed in here, but other devices will be signed out.

Current password

New password

Minimum 12 characters, at least one letter and one digit.

Confirm new password

Connected accounts

Sign in with one click using these providers. Linking ORCID also pulls your iD into your profile.

Account

Account ID and creation date — useful when reporting issues to support.

Member since

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Short ID — share this with support

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Account ID — internal UUID, used by the API

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