Now in early access

Science,
as it should be.

From protocol to publication. One workspace, zero fragmentation, and an AI built for the way science actually works.

AG MK RF JL
Trusted by researchers at Harvard, Stanford,
UofT, NYU, Waterloo, and Columbia
ARIA Research OS
ARIA Sandbox
Enzyme Kinetics Simulation
Simulate Michaelis-Menten kinetics at varying substrate concentrations.
[S] concentration2.4 mM
Vmax12.6 μmol/min
Km0.8 mM
Velocity vs. Substrate Concentration
V [S] Vmax
Dashboard
CRISPR Study — Q2 2026
94%
Transfection
847
Clones
3
Active
Project progress
Cell line validationComplete
Sandbox simulation runs68%
Manuscript draft41%
Journal submission0%
Recent activity
M. Rodriguez ran Sandbox — centrifuge protocol2h
S. Patel updated manuscript draft5h
Protocols
DNA Precipitation Protocol
Generated from Sandbox · Apr 28, 2026
Add 500 μL lysate to 1.5 mL Eppendorf
Complete
Done
Add 50 μL 3M NaOAc (pH 5.2)
Complete
Done
Add 1000 μL ice-cold 100% ethanol
In progress
Now
Incubate at −20°C for 30 minutes
Upcoming
Centrifuge at 14,000 × g for 15 min at 4°C
Upcoming
Document Studio
CRISPR-Cas9 Delivery Mechanisms
Abstract

We present a systematic evaluation of lipid nanoparticle formulations optimized for primary cell transfection efficiency across three mammalian lineages. Editing efficiency was assessed via flow cytometry across 847 independent clones.

The novel methodology demonstrates significant improvements over existing protocols. Studies have shown temperature affects efficiency.

AI Review
Clarity
Abstract is clear. Define "primary hepatocytes."
Argument
"Novel methodology" too vague.
Citation
Temperature claim needs a source.
Journal Intelligence
Nature
IF 64.8 · ≤ 3,500 words
6 / 7 passing
Nature
Cell
NEJM
Science
Citation style converted
47 refs · ok
Abstract within word limit
147 / 150
Figure 3 below 300 DPI
218 dpi
ORCID affiliations verified
6 authors
The problem

Research is broken by the tools meant to support it.

01
Fragmented tools
Manuscripts in Word. Citations in Zotero. Data in Excel. Protocols in a shared folder nobody can find. Eight to twelve tools that never talk to each other.
02
No simulation layer
Testing a hypothesis computationally means hiring a bioinformatician or learning Python. Most researchers skip it and go straight to the bench, burning time and reagents.
03
Journal formatting tax
Reformatting a manuscript for every new submission takes hours, every single time. None of it is science. All of it is overhead that ARIA eliminates.
04
Lab management chaos
Research teams communicate in group chats and email threads with no structured project oversight, milestone tracking, or permission system.
05
Citation overhead
Finding and formatting citations manually is some of the least valuable work a researcher does. ARIA detects uncited claims and resolves them automatically.
06
Wasted time
The average researcher spends more time managing their workflow than doing their work. ARIA is the correction.

"Elsevier recognizes the potential of generative AI and AI-assisted technologies, when used responsibly, to help researchers work efficiently, gain critical insights fast and achieve better outcomes. Increasingly, these tools are helping researchers to synthesize complex literature, identify research gaps, and provide tailored support for tasks such as content organization and improving language and readability."

— Elsevier Generative AI Policies for Journals ELSEVIER
ARIA Sandbox

Test your hypothesis before you touch a single reagent.

The only tool in the world that turns a plain language description of any scientific methodology into a live, interactive simulation. No coding required. No direct competitor exists.

Before ARIA, testing a hypothesis computationally meant hiring a bioinformatician, learning R or Python, or waiting weeks for a collaborator to run your model. Most researchers skipped it entirely and went straight to the bench, burning time and reagents on experiments that a simulation would have caught in minutes.

Describe your experiment the way you would explain it to a colleague. ARIA handles the code, the execution, and the rendering. You get a live parameter dashboard you can explore in real time.

Try the Sandbox
ARIA — Sandbox — DNA Precipitation
Methodology prompt
Precipitate genomic DNA from a 500 μL lysate using 2 volumes of 100% ethanol and 0.1 volume of 3 M sodium acetate at pH 5.2, incubated at −20°C for 30 minutes.
Ethanol volume (×)2.0
NaOAc (M)0.30
Temperature (°C)−20
Predicted yield vs. ethanol volume
94% yield
Why we built this

Built by scientists.
Engineered for research.

ARIA was designed by a Harvard-trained scientist who lived the fragmentation problem firsthand, and a University of Waterloo software engineer who knew it could be solved. Every feature exists because one of us needed it and nothing on the market came close.

AV
Agam Vohra
Research Scientist & Co-founder
Researcher at Princess Margaret Cancer Centre. Researcher at Harvard. Youngest presenter in ASCB conference history. Published his first peer-reviewed first-author paper at 17.
Harvard · UHN
LinkedIn
VZ
Vienna Zhao
Software Engineer & Co-founder
Software engineer and research scientist. Built the full technical architecture of ARIA from the ground up. Deep background in computational biology and research infrastructure.
University of Waterloo
LinkedIn
Early access

Built for the researchers who move science forward.

Early access researchers at leading institutions are already using ARIA to cut submission time, reduce formatting errors, and spend more time on the work that actually matters.

"ARIA cut my submission prep from a full day to under an hour. I don't know how I worked without it."

DR
Postdoctoral Researcher
Harvard Medical School

"The Sandbox alone is worth it. I ran three weeks of experiments digitally before touching a single reagent."

MC
PhD Candidate
Stanford Department of Chemistry
Harvard Stanford University of Toronto NYU Waterloo Columbia

Your next paper
starts here.

Join the researchers already using ARIA to work faster, submit smarter, and spend more time on the science that matters.

Join the waitlist
Free to join. Early access spots are limited.
The full product

Everything you need.
Nothing you don't.

Five deeply integrated features that replace every fragmented tool in your research workflow. Built from scratch for scientists, by scientists.

01 — Idea Engine

From scattered thoughts to structured literature.

Paste any idea, hypothesis, or research direction. ARIA surfaces the most relevant papers, synthesizes the existing literature, and drafts a structured literature review for you.

  • Surfaces relevant papers by scope match and citation weight
    Indexed across Nature, Cell, NEJM, PNAS, and all major journals
  • Synthesizes key themes and ongoing debates
    Cross-referenced across multiple sources, not just the top result
  • Identifies gaps in the literature automatically
    The most valuable section for forming an original research contribution
  • Drafts a full six-section literature review outline
    Export directly to Document Studio in one click
ARIA — Idea Engine
Your idea
The role of mitochondrial dysfunction in early-stage Parkinson's disease and its relationship to dopaminergic neuron loss
Relevant papers
Mitochondrial complex I deficiency in Parkinson's disease substantia nigra
High match
Schapira et al. · Nature · 2023 · 847 citations
PINK1 and Parkin pathways in mitophagy and neurodegeneration
High match
Narendra et al. · Cell · 2022 · 1,243 citations
α-Synuclein aggregation and mitochondrial membrane interaction
Related
Devi et al. · J Neurosci · 2024 · 412 citations
Literature review draft
4 sources synthesized
Mitochondrial Dysfunction in Early Parkinson's Disease

A growing body of evidence implicates mitochondrial dysfunction as a central mechanism in the early pathogenesis of Parkinson's disease, preceding overt dopaminergic neuron loss by years…

Outline structure
1.
Introduction
Overview of Parkinson's pathology and the mitochondrial hypothesis
2.
Mitochondrial Complex I Deficiency
Evidence from postmortem and in vivo studies
3.
PINK1-Parkin Pathway & Mitophagy
Genetic models and impaired mitochondrial clearance
4.
α-Synuclein & Mitochondrial Membranes
Lipid interactions and permeability transition
5.
Gaps & Research Opportunities
Underexplored intersections identified by ARIA
02 — Document Studio

A manuscript editor that works as hard as you do.

Write, edit, and refine your manuscript in a single intelligent editor. ARIA checks your grammar, adjusts your academic tone, flags uncited claims, generates figures from a prompt, and delivers structured peer review feedback before you submit anywhere.

  • Figure and diagram creator from natural language prompt
    Describe a figure, ARIA generates it inline
  • Smart grammar checker and tone editor
    Rewrite for fluidity, clarity, academic tone, or any custom tone
  • AI peer review, structured reviewer-style feedback
    Before you submit anywhere, know exactly what reviewers will flag
  • Auto-citation, detects uncited claims with verified sources
    13 citation styles: APA 7, Vancouver, Nature, IEEE, and more
ARIA — Document Studio
Saved 2s ago
Abstract

Characterization of CRISPR-Cas9 Delivery Mechanisms in Primary Mammalian Cell Lines

We present a systematic evaluation of lipid nanoparticle formulations optimized for primary cell transfection efficiency across three mammalian lineages. Editing efficiency was assessed via flow cytometry and confirmed by Sanger sequencing across 847 independent clones.

The novel methodology demonstrates significant improvements over existing protocols, with transfection rates exceeding 94% in HEK293T cells and 78% in primary hepatocytes. Studies have shown that temperature affects efficiency.

Verified citation
Tone suggestion
Missing citation
03 — Lab OS

Run your lab like a team, not a group chat.

Give every researcher a role. Assign projects and deadlines. Track progress across your entire lab in one place. Built natively for research workflows, not retrofitted from generic project management software.

  • PI creates and manages the full lab workspace
    Assign roles, positions, and permissions to every team member
  • Form sub-teams and assign projects with milestones
    Deadline tracking, progress visibility, and status updates in one view
  • Project management built for research workflows
    Not a retrofit. Not a generic tool with a science skin.
  • Every project connects directly to ARIA's other tools
    Manuscripts, protocols, and Sandbox runs all live in the same project
ARIA — Lab OS — Neurogenetics Lab
Team
JC
Dr. J. Chen
Principal Investigator
PI · Full
MR
M. Rodriguez
Postdoctoral Fellow
Edit
SP
S. Patel
PhD Candidate
View
Projects
In Progress
2
PINK1 knockout validation
M. RodriguezApr 30
Dopaminergic neuron culture
S. PatelMay 08
Under Review
2
α-Synuclein localization paper
M. RodriguezApr 25
Sandbox run, complex I
S. PatelApr 22
Submitted
1
Mitophagy review, Cell Press
Accepted
Dr. ChenMar 14
04 — ARIA Sandbox

Test your hypothesis before you touch a single reagent.

The only tool in the world that turns a plain language description of any scientific methodology into a live, interactive simulation. No coding required. No direct competitor exists.

  • Natural language to simulation, no coding required
    Describe any methodology, ARIA writes and executes the code
  • Interactive parameter editor with live results
    Drag a slider, watch yield, kinetics, or signal update in real time
  • Export any simulation as a publication-ready figure
    Proper axis labels, captions, resolution, ready for a manuscript
  • Universal methodology coverage
    Enzyme kinetics, DNA precipitation, PCR, spectrophotometry, and any method describable computationally
ARIA — Sandbox — Enzyme Kinetics
01 — Describe
Simulate Michaelis-Menten kinetics for an enzyme with Vmax 12.6 μmol/min and Km 0.8 mM across substrate concentrations from 0.1 to 10 mM.
Parsing methodology · 0.6s
02 — Generate
import numpy as np

# Michaelis-Menten
def mm(s, vmax, km):
    return vmax*s / (km+s)

s = np.linspace(0.1, 10, 200)
v = mm(s, 12.6, 0.8)
render(s, v, "V vs [S]")
03 — Explore
Vmax12.6
Km0.8
[S] range10 mM
From plain language to live simulation in under 10 seconds.
05 — Journal Intelligence

Submit to any journal in one click.

ARIA is trained on the submission requirements for every major journal. Select your target and ARIA reformats your entire manuscript automatically. Every change is flagged before confirming. Everything you reject reverts instantly.

  • One-click reformatting for any target journal
    Citation style, abstract structure, figure compliance, word count, cover letter
  • Journal recommendation engine
    Top 5 journals ranked by scope fit and impact factor from your abstract
  • Exhaustive pre-submission checklist
    Auto-generated from the target journal's own author guidelines
  • Community-sourced journal database
    Researchers link new requirements, model learns and expands coverage
ARIA — Journal Intelligence
Formatting for
Nature
impact factor 64.8 · ≤ 3500 words
6 / 7 passing
Submission compliance
Citation style converted
47 refs · ok
Abstract within word limit
147 / 150
Main text ≤ 3,500 words
3,284 / 3,500
Figure 3 resolution below 300 DPI
218 dpi
Supplementary materials packaged
4 files · ok
ORCID and affiliations verified
6 authors

Your next paper
starts here.

Join the researchers already using ARIA to work faster, submit smarter, and spend more time on the science.

Join the waitlist
Feature 04 — ARIA Sandbox

Simulate your hypothesis
before you run the experiment.

A computational modeling surface for wet-lab scientists who have never written a line of code. Describe your system in plain language. Get a working simulation you can actually interrogate.

Status — Under active construction v0.4 · internal alpha
The Sandbox is being rebuilt from the ground up.

We are re-architecting the simulation engine to handle stiff ODE systems, stochastic processes, and multi-scale models in a single unified runtime. Early-access users will get first look when it ships.

This is a model of what the Sandbox experience looks like. The full simulation engine is under active development.
ARIA Sandbox — Live

Describe your experiment.
Watch it simulate.

No code. No Python. No MATLAB. Type a methodology in plain language and ARIA runs the simulation in real time. Every parameter is backed by published literature.

Enzyme kinetics
DNA precipitation
Spectrophotometry
Bradford assay
PCR efficiency
Enzyme Kinetics — Michaelis-Menten
Beer-Lambert · NIST · 847 papers
Live simulation
Velocity vs. [S]
[S] (mM) v₀ (μmol/min) Vmax Km
Vmax
12.6 μmol/min
Km
0.8 mM
Efficiency
15.75 mM⁻¹min⁻¹
All simulations validated against published literature. Parameters are literature-backed ranges.
Run unlimited simulations in ARIA →
What's coming

Four simulation domains. One prompt interface.

No Python, no Jupyter, no MATLAB license. Describe the system — ARIA picks the solver, runs the model, and gives you plots you can push directly into a manuscript figure.

Kinetics & dynamics

Enzyme kinetics, reaction networks, pharmacokinetic compartment models. Stiff ODE solvers with automatic parameter fitting.

Populations & epidemiology

SIR/SEIR/compartmental epidemic models, population dynamics, agent-based outbreaks. Stochastic and deterministic modes.

Statistical modeling

Power analyses, Bayesian inference, mixed-effects regression. Drop in a CSV, describe the design, get the model.

Molecular & cellular

Signaling cascades, gene regulatory networks, diffusion and reaction-diffusion in 2D. Paper-ready figures by default.

Roadmap
Q4 2025
Solver core
Q1 2026
Prompt interface
Q2 2026
Private alpha
Q3 2026
Public launch

Want to try Sandbox
the moment it ships?

We are letting a small number of researchers in first. Priority goes to labs running wet experiments who want a simulation layer before the bench.

Join the waitlist
Pricing

Start free.
Scale with your lab.

3 weeks of full access, free. No credit card required.

Pricing tiers
Pricing tiers are under construction.
Check back soon.

We are finalizing our pricing model. Join the waitlist to be notified when it launches.

Join the waitlist in the meantime.

Early access is free. Get full access for 3 weeks with no credit card required.

Join the waitlist
Free to join. Early access spots are limited.
Our mission

Science was never
supposed to feel like this.

It was supposed to be curiosity, discovery, and experimentation. Somewhere along the way it became project management, formatting, and administrative overhead. The average researcher spends more time managing their workflow than doing their work. ARIA is the correction. We are not building another tool to add to the stack. We are building the thing that removes everything standing between a researcher and their actual work. Science, as it should be.

Why we built this

Built by scientists.
Engineered for research.

ARIA started in two places at once. At Harvard, Agam was living the fragmentation problem from the inside. Every manuscript required hours of reformatting, every citation a scavenger hunt, every experiment an exercise in juggling disconnected tools.

At the University of Waterloo, Vienna was watching the same pattern from the engineering side: a research ecosystem built out of dozens of products that were never meant to work together, bolted on to each other with duct tape and good intentions. The two of them founded ARIA as equal partners. Agam shapes the research experience, informed by years inside academic science. Vienna architects the system that makes it possible. ARIA exists because both of them refused to accept that research had to feel like this.

AV
Agam Vohra
Co-founder & Research Scientist

Researcher at Princess Margaret Cancer Centre (UHN). Researcher at Harvard. Youngest presenter in ASCB conference history. Published his first peer-reviewed first-author paper at 17.

Harvard Princess Margaret ASCB Speaker
linkedin.com/in/agam-vohra
VZ
Vienna Zhao
Co-founder & Software Engineer

Software engineer and research scientist. Built the full technical architecture of ARIA from the ground up. Deep background in computational biology and research infrastructure.

University of Waterloo
linkedin.com/in/vienna-zhao
The problem

Over 40 tools. Zero integration.
One researcher paying the price.

01
Fragmented tools
Manuscripts in Word, citations in Zotero, data in Excel. None of them talk to each other.
02
Journal formatting
Reformatting for every new journal submission takes hours, every single time.
03
No simulation layer
Testing a hypothesis computationally requires coding skills most researchers don't have.
04
Lab management
Research teams communicate in group chats and email threads with no structured oversight.
05
Citation overhead
Finding and formatting citations manually is some of the least valuable work a researcher does.
06
Wasted time
The average researcher spends more time on administrative overhead than on the science itself.
The solution

One system. Every stage of research.

ARIA is an end-to-end research operating system. Five features, deeply integrated, built specifically for the way science actually works.

The ARIA research lifecycle
01
Idea Engine
Literature search, synthesis
02
Document Studio
Manuscript editor with AI
03
Lab OS
Team, roles, projects
04
ARIA Sandbox
Simulate before the bench
05
Journal Intelligence
Reformat, submit, publish
Why now

The research market is ready.
The tools are not.

Every major technological revolution has triggered a corresponding golden age of science. The steam engine gave us thermodynamics. Electrification gave us modern chemistry. Computing gave us molecular biology. AI is next — and the researchers who will define that era are already here, already working, and still using the same fragmented stack they inherited from 2005.

$2.4T
Global R&D spending
Every dollar spent on research passes through a researcher's workflow. ARIA sits at the center of all of it.
8M
Active researchers worldwide
All of them using 8 to 12 disconnected tools. None built with AI as a first principle.
$47B
Research software TAM
Growing 12% annually. Almost entirely owned by Elsevier, Clarivate, and Benchling — built before LLMs existed.
01
Generational shift is happening now
AI-native researchers are entering labs and replacing a generation that resisted adoption. Terence Tao listing an AI as a co-author is the clearest signal of what's coming. The old guard retires. The new generation defaults to AI tools. ARIA is built for them.
02
The enterprise unlock is enormous
A single pharma company running 500 researchers on ARIA at the Lab tier generates $500K ARR from one customer. The Fortune 500 runs thousands of researchers each. Bottom-up individual adoption converts into top-down enterprise contracts — the same motion that built Slack, Figma, and Notion.
03
The Sandbox has no direct competitor
No tool converts a plain language methodology description into a live, interactive simulation. This is not a feature gap. It is a category that does not exist yet. ARIA is not competing for market share — it is creating a new market from scratch.
04
Legacy tools are structurally vulnerable
Elsevier, Clarivate, and Benchling were built for a pre-AI world. Their moats are subscription lock-in and data, not product quality. A single AI-native platform that actually understands how research works can replace all three simultaneously — and capture the switching cost as a retention mechanism.

"Elsevier recognizes the potential of generative AI and AI-assisted technologies, when used responsibly, to help researchers work efficiently, gain critical insights fast and achieve better outcomes."

— Elsevier Generative AI Policies for Journals ELSEVIER

Science,
as it should be.

Join the researchers already using ARIA to spend more time on the work that actually matters.

Join the waitlist
Early access

Get early access
to ARIA.

3 weeks of full access, free. No credit card required. Join the researchers at Harvard, Stanford, UofT, NYU, Waterloo, and Columbia who are already on the list.

No credit card required. 3 weeks of full access. Unsubscribe anytime.

What full access includes.

Idea Engine

Unlimited literature searches, structured review drafts, and paper surfacing from all major indexed journals.

Document Studio

Full AI manuscript editor with peer review, auto-citation, tone editing, and Google Drive export.

ARIA Sandbox

Unlimited simulations from plain language descriptions, interactive parameter editors, and figure exports.

After 3 weeks, free tier limits apply. Pricing tiers under construction.
Trusted by researchers at
Harvard Stanford University of Toronto NYU Waterloo Columbia